­
­
­
­

Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/24840/18
    Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in The more versible Gels
    01-Jan-1970 Research 2018 : January - March
    Juliana Zampoli Boava Papini, Cintia Maria Saia Cereda, Jose Pedrazzoli Junior, Silvana Aparecida Calafatti, Daniele Ribeiro de Araujo, Giovana Radomille Tofoli

    We evaluated pharmacokinetics (PK) and pharmacodynamics (PD) induced by new formulations of tramadol (TR) in\nthermoreversible gels. The poloxamer- (PL-) tramadol systems were prepared by direct dispersion of the drug in solutions with\nPL 407 and PL 188. The evaluated formulations were as follows: F1: TR 2% in aqueous solution and F2: PL 407 (20%) + PL 188 (10%)\n+ TR 2%; F3: PL 407 (25%) + PL 188 (5%) + TR 2%; F4: PL 407 (20%) + TR 2%. New Zealand White rabbits were divided into\nfour groups (

    How to Cite this Article
    CC Compliant Citation: Juliana Zampoli Boava Papini, Cíntia Maria Saia Cereda, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Daniele\nRibeiro de Araújo, and Giovana Radomille Tofoli, â??Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in\nThermoreversible Gels,â? BioMed Research International, vol. 2017, Article ID 5954629, 7 pages, 2017. doi:10.1155/2017/5954629,\nhttps://creativecommons.org/licenses/by/4.0/.
    Download Full Text